Lexogen Showcases Analysis of the Transcriptome of Carriers of Pathological Variants That Cause Alzheimer’s Disease

Oscar Harari, PhD Assistant Professor in the Department of Psychiatry in Washington University in St Louis

Alzheimer’s Disease (AD) is the result of complex interactions between risk factors that cause pleiotropic changes in molecular networks linking a host of biological processes. A variety of genetic factors have been shown to contribute to risk with varying degrees of penetrance. Variants in these genes confer a different transcriptomic profile, and mutation carriers clustered separately from their non-carrier siblings.

New evidences provide support for both neuronal and glial specific pathways contributing to pathogenesis. However, little is understood about how the genetic loci and molecular changes are organized into common networks. Understanding variant-specific effects is of an immense importance for the elucidation of the underlying biology of the Alzheimer Disease. Initial analysis reveals a transcriptional regulation module that link that early-onset autosomal dominant and late-onset sporadic genes.

In this webinar, participants will learn to identify confounding factors that can affect transcriptomic analyses and learn how to address them. They will also learn digital deconvolution approaches to infer cell composition from RNA-seq data and how transcriptomic profiles can reveal gene co-expression networks.

The speaker for this webinar will be Dr. Oscar Harari, an assistant professor in the Department of Psychiatry in Washington University in St Louis.

He received a doctorate in artificial intelligence from the University of Granada, and he was trained in genetics of neurodegeneration in the Lab of Alison Goate, Department of Psychiatry, Washington University in St Louis during his postdoc. In his current role he is the…

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